ICI-199441
Agonist of OPRK1
Structure
In Cells
In Model Organisms
SERP ratings and comments
SERP Ratings
SERP Comments:
Opioid agonist signalling is complex and context dependent. This makes probe definitions complicated. This compound is a very potent kappa opioid agonist with opioid receptor subtype selectivity in some contexts. Two extra papers added here demonstrate that at least this compound has been well annotated and compared with other compounds and can thus guide use. One hesitation for calling this a probe is the lack of broad profiling across other targets.
(last updated: 19 May 2020 )
SERP Ratings
SERP Comments:
Recommended dose for in vivo studies is high when considered in light of the high potency in cell-based assays and the Ki. As a result interpretation of a target specific role in any biological impact of the probe in vivo at this dose should be made with caution and careful consideration of the potential for other targets to contribute to the biological effect.
(last updated: 16 Nov 2020 )
SERP Ratings
(last updated: 16 Nov 2020 )