Garcinol
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Non selective compound
Intended target=KAT2B, EP300 (PCAF, p300); Garcinol has low potency for PCAF and p300 in biochemical assays (IC50=5 uM and 7 um, respectively); Balasubramanyam et al., Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem. 279, 33716-26 (2004).