Diflusinal
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Non selective compound
Intended target=EP300, CREBBP (p300/CBP); this compound is weakly potent (IC50 ~1 mM) against these targets in biochemical assays. It is not a chemical probe. Shirakawa et al., Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife. 5, pii: e11156 (2016).