AB680
AB680 : Reversible Competitive Inhibitor of NT5E
Structure
In Cells
In Model Organisms
SERP ratings and comments
SERP Ratings
(last updated: 10 Aug 2020 )
SERP Ratings
(last updated: 10 Aug 2020 )
SERP Ratings
SERP Comments:
High levels of adenosine with the tumor microenvironment inhibit the activation of T cells and NK cells thereby suppressing the immune function. CD73 is ecto-nucleotidase which catalyses the conversion of adenosine monophosphate (AMP) to adenosine. AB680 is a highly selective inhibitor of the ecto-nucleotidase CD73 however it is a triply charged molecule that requires iv delivery. AB680 demonstrates excellent potency (Ki =5 pM). Furthermore, it shows a desirable slow clearance in several animal models including mouse, rat, dog, and monkey.
(last updated: 5 Sept 2020 )